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405 A CXCR4-targeted mRNA nanoparticle was subsequently developed to induce p53 expression in HCC

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Genetic polymorphisms in Keap1 or Nrf2 further influence individual susceptibility to HTN and response to therapy, highlighting the need for personalized approaches ( 6 Oxidative stress and diabetes mellitus OS in DM operates as both a causal driver and consequential amplifier of disease progression, accelerating metabolic dysfunction and tissue damage in a similar way as in HTN (Papaetis et al., 2025)

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