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Increment of subcutaneous adipose tissue is associated with decrease of elastic fibres in the dermal layer

The primary results from the SELECT trial, published almost two years ago, showed that high-dose semaglutide (the version approved as Wegovy for treating obesity) reduced peoples risk of heart attacks and other major cardiovascular events by 20% during the study period

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The Sniff Test While you should not open the vial to smell it, if you notice a strong, unusual odor when preparing your dose, this could indicate that the preservatives have failed

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SAFETY AND TOLERABILITY The safety profile of semaglutide in ESSENCE was consistent with its known profile from T2DM and obesity trials [10,12]