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The integration of pharmacological and non-pharmacological therapies offers a promising pathway to enhance neuroplasticity, accelerate neurological restoration, and improve quality of life (Fig

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Future priorities should focus on multi-center trials for safety/PK-PD profiling, biodegradable/low-cost lipid matrix development, and omics-guided biomarker discovery to bridge translational gaps, ensuring that LBDDSs achieve their precision medicine potential in gout and hyperuricemia

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