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NAC and GSH exhibited pro-oncogenetic effects on human HCC cells and desensitized NRF2/GCLC related antioxidant production pathway in vitro Since we observed that antioxidants promoted tumorigenesis and growth in mouse spontaneous HCC and xenograft models, we wished to confirm whether these promoting effects also existed in human HCC cells both in vitro and in vivo

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Collectively, these human and experimental studies highlight a contribution of commensal microbiota to intestinal damage associated with CICB

This approach would capitalize both on our understanding of circadian pathophysiological pathways in asthma, and existing redox-targeted therapeutics, whilst minimizing off-target effects associated with hormone based therapies such as melatonin

Frayling TM, Rafiq S, Murray A, Hurst AJ, Weedon MN, Henley W, et al