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An RCT (n=150) found that NAC (1,200 mg/day) plus clomiphene significantly improved ovulation rate and pregnancy rate compared to clomiphene plus placebo (Rizk et al., Fertil Steril, 2005) [58]

In light of these data, it should not come as a surprise that obesity and T2DM have been associated with the over-expression of Ach-degrading enzymesbutyrylcholinesterase (BChE) and acetylcholinesterase (AChE)which tone down cholinergic signaling

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