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Unlike BCTC, exendin 939 also mitigated both thermal and mechanical nociceptive behaviors in mice without inducing hyperthermia, indicating that it is a viable analgesic without the common adverse effects associated with existing pain management strategies, such as opioids and traditional TRPV1 antagonists 32,42,51,52,53

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At her clinic, Barenbaum said she prescribes some GLP-1s off-label, which may involve prescribing a lower dose, most often due to cost and tolerability