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Of the 14 participants enrolled, 13 completed the study, with one participant withdrawing after four weeks due to severe constipation

Therefore, its directionality may vary depending on the stimulatory context and tissue microenvironment

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The first condition evaluated potency of each drug with a lower concentration of CP55940 (50nM or EC 80 ), while the second condition evaluated potency against an elevated concentration of CP55940 (2000nM or 40X EC 80 )

In terms of safety, it was consistent with previous GLP-1RAs level of safety, with no additional safety concerns identified (Husain et al., 2019)

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