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References Leung DYM et al

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Onyda XR is a reformulation of clonidine hydrochloride, which was first approved by the FDA in 1974 to treat high blood pressure

The mechanisms most cited in the literature are promotion of angiogenesis (new blood-vessel formation, linked to VEGFR2 signaling), modulation of growth-factor and nitric-oxide pathways, and interaction with the gut-brain axis

It can also reduce skin pigmentation, age spots, blemishes, pimples, ulcers, freckles, and dark circles

We do not know how much of it is absorbed through the skin, but generally, barring a few chemicals such as hydroquinone, absorption from intact skin is minimal