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PubMed research supports that insulin resistance is a core factor in various health issues beyond diabetes, including fatty liver, cognitive impairment, and cardiovascular disease (Springer)

2020;45(Suppl 1):43-60

Manufacturers are responsible for ensuring safety and accurate labeling, but supplements cannot legally claim to treat, cure, or prevent any disease

If you respond well to appetite suppression as a mechanism, that response is likely to be amplified with GLP-1 medications

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Pioglitazone has lower PPAR agonism compared with rosiglitazone but has more profound effects on MASH, potentially mediated by the mitochondrial target of thiazolidinediones, specifically the mitochondrial pyruvate carrier