Maintain controlled handling environments
L- ( )
Finally, as both increasing age and germ-free conditions have been associated with a decline Drosophila antioxidant responses 22,23 , we defined the requirement of the antioxidant response system in our model and find, in agreement with vertebrate studies, that genetic and pharmacologic manipulations of antioxidant response pathways results in altered sensitivity to APAP toxicity 24,25
Glutathione is your bodys master antioxidant, directly binding to oxidative compounds that damage cell membranes, DNA, energy production, etc
No Jitters
By 3 days post-fertilization, the zebrafish liver is functionally mature and responsive to drug stimuli, enabling robust in vivo DILI studies in larvae