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Efficacy and tolerability of tapentadol for the treatment of chronic low back pain in elderly patients

Epub 2016 Feb 2

When lifestyle measures alone are insufficient, pharmacological options such as Mounjaro, Wegovy (semaglutide), or orlistat may be appropriate for eligible individuals under medical supervision

Most people tolerate semaglutide well

But during training, when I needed to eat, I could eat

One challenge to elucidating a mechanistic role for GLP-1Rs stems from their complex expression across multiple brain regions (1012), including the lateral septal nucleus (LSc), substantia nigra, ventral tegmental area (VTA), amygdala, nucleus accumbens (ACB), hippocampus, several regions of the hypothalamus (paraventricular nucleus of the hypothalamus [PVH], arcuate nucleus [ARH]), and hindbrain