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FIGURE 4 5.1.3 Regulation of autophagy in mammalian cells Multiple kinases are responsible for regulation of mammalian autophagy, among them, the mechanistic target of rapamycin (mTOR) and adenosine monophosphate (AMP)-activated protein kinase (AMPK) play important and antagonistic roles (Tamargo-Gmez and Mario, 2018)

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Reproductive system damage, which is often linked to POI, is one of the most disastrous consequences of chemotherapy 9,10,11

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