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Pressure from leaning on an elbow creates disproportionate discomfort
Outcome measures in clinical trials will have to track these comorbidities, so that different subgroups of IC/BPS patients can be identified and responders versus non-responders categorized appropriately
Outcomes relied on the accuracy of diagnoses and prescriptions recorded in the database
doi: 10.3389/fimmu.2020.00308 247
Despite the positive results, due to the limited number of included studies, further randomized controlled trials are needed to investigate the safety and efficacy of SGLT2i and GLP-1RAs as first-line treatment options for patients with T2DM at low cardiovascular disease risk, particularly when compared to metformin
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