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While co-receptor targeting, as seen with AMG133, has shown promising results in weight reduction, it remains unclear whether this is an additive or synergistic effect, or if the main mode of action behind appetite suppression is based on GLP-1 receptor activation (104)

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The researchers found that the Ozempic shot can make the contrast solution used for PET scans show up in abnormal patterns

9 Use of DPP4-inhibitors in older frail populations Oral DPP-4 inhibitors have few notable side effects and are associated with a minimal risk of hypoglycaemia