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In Trial 1, patients received double-blind monotherapy with lamotrigine 50 mg/day (n=50), lamotrigine 200 mg/day (n=124), lamotrigine 400 mg/day (n=47), or placebo (n=121)

Notably the medication can lead to visceral fat loss, which is the potentially dangerous fat in the abdominal area that surrounds the organs

The Russian clinical trial context deserves specific mention

Collectively, reviews place the proportion of lean mass in total weight loss at ~15% to 40% (or higher in select settings), reflecting differences in drug, dose, baseline composition, and duration

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Mitochondrial calcium uniporter blocker effectively prevents brain mitochondrial dysfunction caused by iron overload