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The selectivity of the peptide is further discussed by the researchers, who suggest that senescent cells may depend more strongly on FOXO4-mediated control of p53 localization and activity, so disrupting that node might preferentially remove cells that are already operating close to an apoptotic threshold
Concluding, final evidence belongs to the consistent effect of the two distinctive regimens, given either once time daily, as intraperitoneal administration, or perorally, continuously in the drinking water (providing also the evident effect of once time initial intragastric administration), and application of the two different dose range
