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Male pattern baldness progresses in stages, from early thinning at the hairline to complete baldness in severe cases

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FLAD1 loss-of-function results in early-onset mitochondrial dysfunction, myopathy, and metabolic acidosisphenotypes characteristic of FAD deficiency. However, many patients retain partial enzyme activity and show clinical response to riboflavin

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Mol Cell (2001) 7(6):115363.10.1016/S1097-2765(01)00264-7 133 NakataniYKanetoHKawamoriDYoshiuchiKHatazakiMMatsuokaTAet alInvolvement of endoplasmic reticulum stress in insulin resistance and diabetes