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This could lead to bonking, dehydration, or serious GI issues

Simultaneously, hormones like ghrelin (the hunger hormone) rebound, often rising above their pre-treatment levels temporarily

Energy often improves as body weight decreases

Factors associated with better response include younger age, shorter duration of obesity, and adherence to lifestyle modifications

[DOI] [PubMed] [Google Scholar] 163.Arora S, OBrien C, Zeuzem S, Shiffman ML, Diago M, Tran A, et al

Priming signals and cytokine milieu Neutrophil activation in PCOS unfolds within a pro-inflammatory cytokine microenvironment characterized by elevated concentrations of interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-), and interleukin-1 (IL-1)cytokines that collectively orchestrate neutrophil recruitment, priming, and effector activation [8]