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In the Study of Tirzepatide in Participants with Heart Failure with Preserved Ejection Fraction with Obesity (SUMMIT) trial, tirzepatide significantly reduced the risk of death from cardiovascular causes or worsening heart failure events in patients with heart failure with preserved ejection fraction (ejection fraction 50% and above) and obesity (BMI 30 kg/m 2 ), compared with placebo (HR 0.62

Positive Contracts signed with CRO to conduct Human Pilot Study #7 Study uses 5-week, three-arm parallel design to assess safety and PK First-time use of a DHT-sema oral tablet formulation First multi-week human evaluation of DHT-sema formulations containing SNAC Study fully funded from existing corporate resources Negative Independent ethics approval is still pending before patient recruitment No PK, safety, or efficacy results available yet from this study Prior DHT-sema studies were single-dose, limiting comparative multi-dose data News Market Reaction LEXX In the Apr 1 session, LEXX gained 11.04% , reflecting a significant positive market reaction

2) revealed low-density lesions of the right mandible, with unclear boundaries

Proc Natl Acad Sci U S A 2007;104:6436-6441

It significantly increases IGF-1 levels

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