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A few of the most significant contributors to NAD+ depletion include: CD38: An enzyme that breaks down NAD+ and becomes more active with age, especially in response to inflammation

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635,636,637,638 Therefore, the neuroprotective activity of P7C3 offers a new pharmacotherapy for age-associated ALS, Alzheimers disease and Parkinsons disease

Chronic allopregnanolone treatment accelerates Alzheimer's disease development in APP(Swe)PSEN1(E9) mice