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Over time, obese patients lose roughly 12% of their body weight on Wegovy (semaglutide) and about 18% on Zepbound (tirzepatide, which targets GLP-1 and another gut hormone, GIP.) Diana Thiara, MD, medical director of the UCSF Weight Management Program, says the results can be amazing and life-changing for people with obesity, a condition linked to a host of health risks
This occurs because GLP-1s are hormones that affect the brain's hunger signals and work on the stomach lining to signal fullness
It increases muscle protein synthesis, reduces protein breakdown, supports glucose and amino acid uptake, and suppresses programmed cell death
Microdosing GLP-1 drugs is gaining popularity among people seeking to lose weight
While direct human trials on the combination for cognition are sparse, the mechanistic synergy supports potential for addressing mitochondrial dysfunction in age-related cognitive decline [5]
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