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Fatigue in the first couple weeks is normal as your caloric intake drops and your body adapts

The study, which focused specifically on prescription amphetamines, not illicit street drugs, concluded: "Caution should be exercised when prescribing high doses of amphetamines, with regular screening for symptoms of psychosis or mania." The findings were published in September 2024 in the American Journal of Psychiatry

Bostrom MP, Gamradt SC, Asnis P, Vickery BH, Hill E, Avnur Z, et al