However, the NADPH-oxidase activity (which also uses NADPH as a cofactor) is increased (producing H 2 O 2 ) during active vitiligo, therefore increasing ROS and promoting an active competition with EAS enzymes for NADPH molecules, a molecule already reduced in active vitiligo patients (Shajil and Begum, 2006)
In these studies, Epithalon administration in elderly or immunosuppressed animals leads to increased production of thymic peptides and improved immunological parameters, including CD4/CD8 ratios and natural killer (NK) cell activity [3]
It also avoids the added risks that come with injections, including sterility, sourcing, dosing, and product purity
This absence of formal research means that any combined use is based on extrapolation from individual drug studies, theoretical pharmacology, and anecdotal clinical experience rather than robust evidence
Doctors in the UK are expected to practice in line with evidence-based guidelines, but they must consider individual patient circumstances, local resources, and the specific guidance from their respective health systems
Hence Glutathione disulfide (GSSG) quantification can be done after reducing it to its corresponding thiol (GSH)
