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In experiments administering GIP and GLP-1 individually or together, only GLP-1 infusions lowered plasma glucose and suppressed glucagon, whereas simultaneous infusion of GIP abolished the inhibition of glucagon observed with GLP-1 [63]

In December 2025, the Trump administration announced the BALANCE Model a new federal program that could expand access to GLP-1s through both Medicare and Medicaid beginning as early as May 2026