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Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide

Statements Author contributions AH: Conceptualization, Writing original draft, Writing review & editing

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It is still too early to draw definitive conclusions, but the numerous ongoing clinical trials, including the cardiovascular safety trial versus an active comparator (dulaglutide), the first of its kind, will provide us shortly with important confirmations

CagriSema-style escalation starts at 0.25 mg per week with semaglutide and steps up every 4 weeks (0.5, 1.0, 1.7, 2.4 mg) over 16 weeks

1000-4000