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Moreover, due to the reconstruction of context-specific models for hundreds of thousands of cells being a limiting step in our analysis, we based our approach on Recon2.2 19 which is much smaller in size than more current reconstructions of human metabolism, like Recon3D 77

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This approach is generally considered safer because it works in harmony with your body's intricate endocrine system, rather than forcing a hormonal change upon it

Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT