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Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated substantial weight loss in participants with obesity, though these findings were generated under tightly controlled conditions with rigorous medical supervision

The resulting drug, Rybelsus, was approved by the FDA in 2019

For the full Phase 3 safety profile, see our complete retatrutide side effects guide

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When Lilly presented retatrutides early Phase 2 numbers at a medical conference in 2023, a scientist in the room told The Atlantic the usually staid audience broke into spontaneous applause

However, because federal law does not require state-licensed pharmacies that are not outsourcing facilities to submit adverse events to FDA, many cases are likely going undocumented