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We further investigated whether conversion to glutamate is required for the action of glutamine, by application of the glutaminase inhibitor DON in non-permeabilised and -haemolysin-permeabilised cells

Competitive Insights Chapter 3

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This observation is consistent with evidence demonstrating reductions in high-sensitivity CRP (hs-CRP), highlighting a broader anti-inflammatory and anti-atherosclerotic profile of this drug class ( Beyond these established biomarkers, emerging molecular signatures such as circulating microRNAs (miRs) are increasingly recognized as sensitive indicators of early atherosclerotic changes and may provide additional insight into GLP-1RA-mediated vascular effects

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