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Induction of the hepatic CYP2B and CYP3A enzymes by the proestrogenic pesticide methoxychlor and by DDT in the rat

FIGURE 3 Munkboel et al

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After correction using the ComBat method ( Supplementary Figures 1C, D ), dataset differences among samples significantly decreased, and the clustering structure of RA and normal control groups in principal component space became clearer, indicating that the data processing workflow effectively enhanced data quality and the reliability of subsequent analyses

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