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The meniscus, a fibrocartilaginous structure essential for load transmission, shock absorption, and joint congruency, exhibits significant degenerative changes in OA

This is the crux of the dosing question: the failure to replicate cannot be attributed to underdosing relative to the original protocol, because the dose was matched

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Alternatively, when dietary protein intake is low and blood levels of SAM fall, homocysteine undergoes remethylation to form methionine