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Many individuals with Hashimoto's thyroiditis face weight gain and insulin resistance alongside thyroid dysfunction, making tirzepatide an attractive option

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Specifically: on one hand, EVs from obese individuals may carry miRNAs and other molecules that regulate insulin signaling, affecting the reduced sensitivity of target cells to insulin

The peptide contains an internal disulfide bond between the two cysteine residues, which is critical for its three-dimensional conformation

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