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Since the first discovery of flavonoid in 1937, a number of flavonoid sulfates with structural variation were reported in various plant species ( After completion of biosynthesis, secondary metabolites like GSLs and flavonoids, which are present at high concentrations in the cell, need to be imported into the vacuole ( Figure 2 , the identity is unknown), stored there or further metabolized and/or transported ( Figure 3 , transporters 16 and 17)
In liver cells, the MCFAs, again, avoid activation in the cytosol and enter mitochondria, where they get activated to undergo -oxidation to produce acetyl-CoA (13)
However, the above studies have not clarified the differences in efficacy between PCs structures and total extracts, nor the specific targets of individual metabolites
In Arabidopsis , bZIP19 and bZIP23 act as zinc deficiency sensors, regulating nuclear protein activity and cellular zinc status (Campilho et al
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