In our study, a significant decline of ATP level was found in the hippocampal of both WT and APP/PS1 mice after ethanol exposure, and a greater decline of ATP level was observed in APP/PS1 mice compared to WT mice
This event causes the relocation of PGAM5 to the mitochondria [74]
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This contributes to the scientific hypothesis that administration of MOTS-c may contribute mitochondrial homeostasis, and impart an anti-aging effect on those treated