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The problem is that production drops dramatically with age

However, the NAC monotherapy arm (600 mg three times daily) showed a trend toward slower decline in forced vital capacity (FVC) that did not reach statistical significance compared to placebo (Martinez et al., N Engl J Med, 2014) [45]

TB-500 shows systemic distribution characteristics enabling whole-body effects[19]

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Others are synthesized by the body and are therefore "non-essential", like Vitamin D for example