The factors contributing to bone impairment in individuals with PWS are not fully understood, but possible explanations include loss of function of genes in the q11-q13 region of the paternal copy of chromosome 15, reduced production of sex hormones during puberty, as well as a relative GHD during childhood and adolescence (79)
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Moreover, among semaglutide-treated participants in the STEP 1 trial, 34.8% lost 20% or more of their body weight by week 68 compared to 47.06% in BARI-STEP, while 74.8% compared with 85.29% had weight loss of 10% or more, respectively
Real weight management is rarely dramatic, predictable, or identical from person to person
Multiple large cardiovascular outcome trials with novel glucose-lowering agents like GLP-1 have demonstrated robust and significant reductions in major adverse cardiovascular events and additional cardiovascular outcomes, such as hospitalizations for heart failure in a diabetic population
Liver diseases related complications represent a significant source of morbidity and mortality worldwide, creating a substantial economic burden
