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I would be very interested on your take on two things1) the very high discontinuation rate of these drugs (and the corresponding need for a focus on behavior change as an adjuvant/parallel to course of treatment) and, 2) the impact of significant lean muscle and bone loss during treatment w/GLP-1s

My energy levels reminded me of my late twenties

Mol Biol Rep 49(3):22732281

J., & Malhotra, A

If the remaining Phase 3 readouts hold and the FDA filing proceeds on the projected late- 2026 timeline, retatrutide is positioned to arrive as the unambiguous class leader and the first obesity drug whose efficacy curve starts to genuinely overlap with bariatric surgery

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