retatrutide and heart rate Does Cause Problems? What the Research Actually Shows Retatrutide Side Effects Research |

Some less common effects that may appear during this phase include increased heart rate (a known class effect of GLP-1 receptor agonists), skin hyperesthesia in rare cases, and temporary elevations in liver enzymes (alanine aminotransferase)

More recently, orally active small-molecule GLP-1R agonists have emerged as an alternative to injectable peptide drugs

One notable difference is the time required to reach maximum dose

As with other GLP-1s, gastrointestinal adverse events (nausea, constipation, diarrhea and vomiting) were the most common but were typically mild-to-moderate

GLP-1 receptor agonists work by slowing gastric emptying, reducing appetite, and improving insulin sensitivity

In addition, recent studies suggest that GLP-1s may be linked with a rare yet serious condition called nonarteritic anterior ischemic optic neuropathy (NAION)