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The GIP receptor (glucose-dependent insulinotropic polypeptide) controls appetite and metabolic function independently from GLP-1, creating a more comprehensive signal to reduce hunger and increase satiety

It is a naturally occurring peptide made up of nine amino acids that was first identified in the 1970s during experiments investigating sleep physiology

Tirzepatide (going by the brand names Mounjaro and Zepbound) is the only dual agonist currently approved in Canada

They found that around 40% of patients had stopped their GLP-1 medication within the first year, and almost 60% had stopped by the end of two years

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