178 Overexpression of HSP27 is strongly associated with tumorigenesis, metastasis, and poor prognosis in various cancers, including head and neck squamous cell carcinoma, pediatric acute myeloid leukemia, breast cancer, and colorectal cancer
NNT knockdown shows limited ability to maintain NADPH levels and reduces tumorigenicity under oxidative stress conditions, such as that induced by anoikis, glucose deprivation in vitro, or impairs peritoneal dissemination and lung metastasis in vivo
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