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We check lab markers before recommending injections
Start by speaking to your GP, who can assess your individual circumstances and refer you to appropriate NHS weight management services, including structured lifestyle programmes or specialist tier 3 or tier 4 services for complex cases
Available evidence from diabetes and obesity trials demonstrates substantial weight regain after discontinuation of GLP-1 RAs, reaching pre-treatment levels in some cohorts within 12-18 months of cessation, with accompanying deterioration in cardiometabolic parameters [72]
GLP-1 is secreted by intestinal L cells and brainstem neurons and exerts effects via GLP-1 receptors (GLP-1Rs), which are expressed in mesolimbic reward areas, including the ventral tegmental area (VTA), nucleus accumbens (NAc), amygdala, and hippocampus [7]
This starting dose helps your body adjust to the medicine and reduces adverse effects, such as nausea or stomach pain