These include potentially inappropriate application of effects observed in populations with high cardiovascular risk in more general populations with type 2 diabetes, and risking double counting of benefits in modeling analyses where changes in surrogate physiological parameters that affect the incidence of cardiovascular complications (such as HbA1c, blood pressure, serum lipids and BMI) have already been applied (as the mechanisms of action behind the benefits observed in CVOTs are not yet understood) [55, 56]
Limitations: Lower bioavailability and inconsistent dosing
Deeper Biological / Functional Medicine Explanation To understand where GLP-1 medications fit and where they don't we need to look beneath the surface of metabolism, gutbrain signaling, hormones, inflammation, and detoxification
Phase 1: Weeks 13 (Disc Repair Priority) BPC-157: 500mcg/day subQ TB-500: 2.5mg/week subQ GHK-Cu: 1mg/day subQ Focus: disc tissue repair, nerve decompression, anti-inflammation Activity: physical therapy, gentle mobility, no loading Phase 2: Weeks 48 (Add Recomp Layer) Continue Phase 1 stack Add CJC-1295 no DAC + Ipamorelin: 100mcg each, pre-bed This layer drives GH pulsatility for tissue remodeling and begins the body recomposition phase Activity: begin light lifting as cleared by PT Phase 3: Weeks 9+ (Maintenance and Fat Loss) TB-500: Drop to maintenance 1.25mg/week BPC-157: Can drop to 250mcg/day or 5 days/week CJC+Ipa: Continue pre-bed Optional add: Tesamorelin (12mg/day, 5 days/week) for visceral fat and GH optimization pairs well with CJC+Ipa Optional add: Retatrutide for more aggressive fat loss if that's a priority What to Expect: Recovery Timeline Weeks 12: Reduced acute nerve pain is often the first noticeable change
Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity
Most people think theyre hitting their goals until they see the numbers
