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It is possible that loss of GLP-1 responsivity, simultaneous with preservation of GLP-2 activity (32), may shift the enterocyte to a state favoring enhanced lipid secretion, a hypothesis that should be tested in future experiments
Of the two adverse reports Novo Nordisk is accused of not properly reporting, one is from a patient who experienced a stroke, and the other is from a patient who committed suicide
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Additionally, these agents suppress glucagon secretion from pancreatic alpha cells, which helps prevent excessive glucose production by the liver