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Mallach et al., 2024), tauopathy (De Strooper and Karran, 2016), lysosomal dysfunction (Nixon and Rubinsztein, 2024), acidification and Ca 2+ dyshomeostasis (LaFerla, 2002), and vasculature damage and angiopathy (Zlokovic, 2011) have been investigated long time

Our real-world analysis of over 10,000 racially/ethnically diverse adults from the NIH All of Us research program, newly initiated on GLP-1 RAs, provides important complementary insights into comparative safety profiles, though findings remain mixed across studies

With the advent of larger data sets, Polygenic Risk Scores are getting better and better, particularly at identifying people at the extremes

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Hu E, Wang D, Chen J, Tao X (2015) Novel cyclotides from Hedyotis diffusa induce apoptosis and inhibit proliferation and migration of prostate cancer cells