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Overall, across the entire 88 weeks, participants on Tirzepatide lost about 25% of their starting weight, while those on placebo lost about 10%

For me, this was a substrate and cofactor story, not an oxidative stress story

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While there is no guarantee that it will stop nausea entirely, many patients and clinical observations suggest that injecting into the thigh can reduce the severity of gastrointestinal side effects

These symptoms rarely persist long-term and often reflect your body's metabolic shift rather than a reason to discontinue treatment

10.1016/j.bioorg.2017.02.011 20 KharbR.HaiderK.NehaK.YarM