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Vitamin D receptor alleviates lipid peroxidation in diabetic nephropathy by regulating ACLY/Nrf2/Keap1 pathway

Similar content being viewed by others Introduction Recently, Guevara-Aguirre et al reported on 99 Ecuadorian individuals with Laron syndrome due to growth hormone receptor ( GHR ) deficiency and congenital insulin-like growth factor-1 (IGF-1) deficiency who did not develop type 2 diabetes (T2D) and were almost free of cancer, in contrast to their healthy relatives with normal insulin/IGF-1 signaling (IIS) [1]

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Luz del Mar et al., 2023, studied the effect of cocoa polyphenol extract against reactive stress-induced cellular senescence, showing that there was an attenuation of senescent phenotypes and oxidative DNA damage, reducing mitochondrial dysfunction by inhibiting the generation of mitochondrial ROS (mtROS)

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