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Stay Hydrated Dehydration is one of the most common contributors to fatigue while taking GLP-1s, especially if youve experienced side effects like nausea, diarrhea, or vomiting

Scientists suggest that by interacting with the GLP-1R in adipose tissue, liraglutide may also reduce the release of triglycerides in the bloodstream and thereby increase insulin sensitivity [10]

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Pills are also easier to manufacture than injectable pens, which could help avoid the frustrating supply problems that slowed earlier GLP-1 launches

Some of these medications can also interfere with the effectiveness of birth control pills when first started, which is why backup contraception is often advised, Murphy says