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The aim of this review was to analyze the interplay among intestinal NAD + biology, nutritional components, and intestinal homeostasis, including GLP-1 production, and explore the pathophysiological significance and therapeutic potential of intestinal NAD + biology in systemic glucose metabolism

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We observed no diarrhea after acute administration of liraglutide

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In an in vivo study, the acute treatment with GLP-1 in female rats resulted in the increase of the amplitude of the preovulatory LH surge, likely by the activation of the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons [35]

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