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The cardiac benefits of GLP-1 agonists were not anticipated before outcome studies were performed for several reasons: (1) Historical Precedent-past experiences with other diabetes medications that unexpectedly had adverse cardiovascular effects made it less likely for researchers and clinicians to anticipate potential cardiovascular benefits without concrete evidence from large-scale trials

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Gut microbiota: novel therapeutic target for nonalcoholic fatty liver disease

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"It's well below 50% of those will cover these medications for the weight-related issues," Peavie said

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Low-quality products may contain fillers or formulations with limited bioavailability

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