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Wilson disease (WD) is an orphan, inherited, progressive and severely debilitating disorder of copper metabolism which is lethal if left untreated

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Problem : Degrades within days, loses effectiveness

Notably, neither of these reports investigated glutathione or oxidative stress, but an earlier report found obese mice had defective leukocyte lysis and lowered GSH levels (34)

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secretory phenotype (SASP) Interest in how modulation of senescent-cell burden affects tissue in research settings