However, seek urgent medical attention (call 999 or go to A&E) if you experience: Severe, persistent abdominal pain (with or without vomiting) which could indicate pancreatitis Signs of a severe allergic reaction (rash, swelling, difficulty breathing) Severe, persistent vomiting or diarrhoea causing dehydration Yellowing of the skin or eyes (jaundice) For less urgent concerns, your healthcare provider may: Review your current medications to identify any other drugs that might contribute to sleep disturbances Assess your blood glucose control , including checking for nocturnal hypoglycaemia Evaluate gastrointestinal symptoms and consider dose adjustments or supportive treatments to minimise nausea and discomfort Screen for co-existing conditions such as sleep apnoea, anxiety, or depression that may require separate management If you suspect nocturnal hypoglycaemia (symptoms include sweating, trembling, confusion upon waking), check your blood glucose if possible

*Note: the syringes we use are very small and painless, you can do it
The liver as an endocrine organ-linking NAFLD and insulin resistance
Skin pinching Gently pinch a fold of skin to ensure subcutaneous injection
Rakipovski G, Rolin B, Nhr J et al (2018) The GLP-1 analogs liraglutide and semaglutide reduce atherosclerosis in ApoE-/- and LDLr-/- mice by a mechanism that includes inflammatory pathways
PlexusDx's compounded tirzepatide injection is $289/mo month-to-month (or $249/mo on the 6-month plan), and GLP-Squared injection (semaglutide + tirzepatide dual compound) is $289/mo month-to-month, or from $249/mo on the 6-month plan, offering cost-effective alternatives if semaglutide alone isn't delivering the appetite control you need